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Proton-pump inhibitors (PPIs) are the first drug of choice for preventing ulcers in high-risk individuals.

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Below is the video from a flexible laryngoscopy that demonstrates some of the findings seen in patients with LPR.

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Lansoprazole and rabeprazole also seemed to have a weaker potential for interactions than omeprazole, but this was based on limited evidence only.

In addition, the AHRQ found no difference between individual PPIs (omeprazole, lansoprazole, pantoprazole, and rabeprazole) for relief of symptoms at 8 weeks.

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Hepatic Disease: In a single dose study of 10 patients with chronic mild to moderate compensated cirrhosis of the liver who were administered a 20 mg dose of rabeprazole, AUC 0-24 was approximately doubled, the elimination half-life was 2- to 3-fold higher, and total body clearance was decreased to less than half compared to values in healthy men.

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